LUO Lan¹ , YIN Hui-Jun² , ZHANG Ying² , JIANG Yue-Rong² , LIU Ying² , SHI Da-Zhuo² (1 . Department of Cardiovascular Diseases, Medical College, Jiamusi University , Jiamusi , Heilongjiang Province 154007 , China; 2 . Department of Cardiovascular Diseases , Xiyuan Hospital , China Academy of Tradi tional Chinese Medcine, Beijing 100091 , China)

ABSTRACT Objective: To observe the effect of ginseng fruit saponins (GFS) on insulin sensit ivity index in high fat-fed rats . Methods: An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ ) in high fat-fed rats . Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique . Results: The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group ( P < 0 .05 , P < 0 .01) , while the index of GIR decreased significantly ( P < 0 .01 ) . As compared with the untreated group, the parameters of GFS-treated groups were improved significantly in a dosage-dependent manner ( P < 0 .05 , P < 0 .01 ) . Conclusion: GFS can improve experimental insulin resistance in rats .

KEY WORDS ginseng fruit saponins; insulin resistance; insulin sensitivity index

J Chin Integr Med, 2005 , 3 (6 ) : 463-465

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